DNA ligases seal 5′-PO4 and 3′-OH polynucleotide ends by using three nucleotidyl transfer steps involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are vital guardians of genomic integrity, and ligase dysfunction underlies human genetic sickness syndromes. Crystal constructions of DNA ligases bound to nucleotide and nucleic acid substrates have illuminated https://devinlhasl.onesmablog.com/details-fiction-and-betting-in-thailand-68390587