DNA ligases seal five′-PO4 and three′-OH polynucleotide ends by way of 3 nucleotidyl transfer actions involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are necessary guardians of genomic integrity, and ligase dysfunction underlies human genetic disease syndromes. Crystal structures of DNA ligases certain to nucleotide and nucleic acid substrates have https://richarde169eim9.blogsvila.com/profile