Activation of neuronal CB1 receptors leads to inhibition of adenylyl cyclase and diminished neurotransmitter release as a result of blockade of voltage-operated calcium channels.[46,65,125] The activation of such signaling pathways by CB1 receptors as well as significant levels of these receptors on presynaptic terminals indicates that endocannabinoid stimulation of CB1 https://personal-injury-compensat97418.blog5.net/76130101/cannabis-flower-no-further-a-mystery