Analysis into conolidine has triggered discovery of the opioid receptor in the body known as ACKR3/CXCR7. ACKR3 seems to be one of the most sought after goal for conolidine, which also disregards the opposite 4 classical opioid receptors(3). Conolidine has been found in the tabernaemontana divaricata plant, that's from https://www.proleviate.com/post/conolidine-an-alternative-natural-pain-relief-to-replace-traditional-painkillers